Article

Antigen-level resolution of commensal-specific B cell responses enabled by phage-display screening and B cell tetramers

2023-10-17

Abstract excerpt

<h4>Summary</h4> Induction of adaptive immune responses to commensal microbes is critical for tissue homeostasis, and perturbation of these responses is associated with multiple chronic inflammatory disorders. However, the mechanisms underlying the induction and regulation of mucosal B cells targeting commensal microbes remain poorly understood, in part due to a lack of tools to identify commensal-specific B cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6433bc7e-710f-55ac-a36a-636242a721cf
DOI: 10.1101/2023.10.13.562275

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antigen-level resolution of commensal-specific B cell responses enabled by phage-display screening and B cell tetramersDOI 10.1101/2023.10.13.562275Read

High throughput profiling of the B cell repertoire identifies systematic changes in the repertoire of individuals with Crohn’s diseaseSemantic proximity Read

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.Semantic proximity Read

Antibody responses against bacterial glycans affinity mature and diversify in germinal centersSemantic proximity Read

Development, High-Throughput Profiling, and Biopanning of a Large Phage Display Single-Domain Antibody LibrarySemantic proximity Read

Mapping adaptive immune responses toward fungal antigens in inflammatory bowel disease using T cell repertoire sequencing and phage-immunoprecipitation sequencingSemantic proximity Read

Natural polyreactive IgA antibodies coat the intestinal microbiotaSemantic proximity Read

Remodeling of human colon plasma cell repertoire in ulcerative colitisSemantic proximity Read

Prevalence, persistence, and genetics of antibody responses to protein toxins and virulence factorsSemantic proximity Read

Simultaneous Profiling of the Blood and Gut T and B Cell Repertoires in Crohn’s Disease and Symptomatic Controls Illustrates Tissue-specific Alterations in the Immune Repertoire of Crohn’s Disease PatientsSemantic proximity Read

Distinct systemic and gut IgA responses to bacteria of the human upper gastrointestinal tractSemantic proximity Read

Teleost IgD+IgM- B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles.Semantic proximity Read

T-bet Expressing B cells are Key Determinants of Protective Immunity Against Norovirus InfectionSemantic proximity Read