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Antibody repertoire analysis in polygenic autoimmune diseases

25 Mar 2018

Abstract excerpt

High-throughput sequencing of the DNA/RNA encoding antibody heavy- and light-chains is rapidly transforming the field of adaptive immunity. It can address key questions, including: (i) how the B-cell repertoire differs in health and disease; and (ii) if it does differ, the point(s) in B-cell development at which this occurs. The advent of technologies, such as whole-genome sequencing, offers the chance to link...

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PMID: 29574826
DOI: 10.1111/imm.12927

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