Article

Mechanism-Aware Protein-Protein Interaction Prediction via Contact-Guided Dual Attention on Protein Language Models

2025-07-08

Abstract excerpt

<title>Abstract</title> <p>Accurate prediction of protein-protein interactions (PPIs) is essential for understanding cellular mechanisms and disease. However, existing deep learning models often fail to generalize to novel proteins with low sequence similarity to training data. Here, we present a mechanism-aware deep learning framework to enhance generalization by incorporating residue-level interaction modeling....

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Literature Corpus work: 4091629b-075e-538d-b2bd-6136518ce40b
DOI: 10.21203/rs.3.rs-7050339/v1

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