Article

Hierarchical Deep Learning Framework Integrating Structural Interaction Potentials and Evolutionary Information for Protein-Protein Interaction Affinity Prediction

2026-01-12

Abstract excerpt

Protein-protein interactions (PPIs) are fundamental to cellular biology, making accurate prediction of protein-protein interaction affinity (PPIA) crucial for drug discovery and disease mechanism elucidation. Existing computational methods often lack explicit physical constraints or operate as “black boxes,” hindering interpretability and generalization. To address these limitations, we introduce StructFuncNet, a...

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Literature Corpus work: 21076977-4d4d-54d4-980a-d1098c79ec4f
DOI: 10.64898/2026.01.12.698948

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