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Article

Deep Local Analysis deconstructs protein-protein interfaces and accurately estimates binding affinity changes upon mutation.

Bioinformatics (Oxford, England) - 30 Jun 2023

Mohseni Behbahani Yasser, Laine Elodie, Carbone Alessandra

Abstract excerpt

MOTIVATION: The spectacular recent advances in protein and protein complex structure prediction hold promise for reconstructing interactomes at large-scale and residue resolution. Beyond determining the 3D arrangement of interacting partners, modeling approaches should be able to unravel the impact of sequence variations on the strength of the association. RESULTS: In this work, we report on Deep Local Analysis,...

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PMID: 37387162
DOI: 10.1093/bioinformatics/btad231
PMCID: PMC10311296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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