Article

ReadZS detects cell type-specific and developmentally regulated RNA processing programs in single-cell RNA-seq

2021-10-01

Abstract excerpt

RNA processing (RNAP), including splicing and alternative polyadenylation, is crucial to gene function and regulation, but methods to detect RNAP from single-cell RNA sequencing data are limited by reliance on pre-existing annotations, peak-calling heuristics, and collapsing measurements by cell type. We introduce ReadZS, the first annotation-free statistical approach to identify regulated RNAP in single cells. Re...

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Literature Corpus work: dfc2a0d6-60ce-51e2-bed4-aef672e85030
DOI: 10.1101/2021.09.29.462469

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