Article

Sierra: discovery of differential transcript usage from polyA-captured single-cell RNA-seq data

2019-12-06

Abstract excerpt

High-throughput single-cell RNA-seq (scRNA-seq) is a powerful tool for studying gene expression in single cells. Most current scRNA-seq bioinformatics tools focus on analysing overall expression levels, largely ignoring alternative mRNA isoform expression. We present a computational pipeline, Sierra, that readily detects differential transcript usage from data generated by commonly used polyA-captured scRNA-seq te...

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Literature Corpus work: 63762281-c0dd-5038-820d-ee62d28a287a
DOI: 10.1101/867309

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