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Article

AEnet: a practical tool to construct the splicing-associated phenotype atlas at a single cell level.

GigaScience - 6 Jan 2025

Liu Shang, Chen Xi, Huang Xiaohu, Wang Yuhang, Huang Waidong, Qin Pengfei, Li Rui, Zou Xuanxuan, Pang Wending, Huang Xiaoyun, Liu Shiping, Bai Yinqi, Wu Liang

Abstract excerpt

Alternative splicing (AS), a crucial driver of proteomic diversity, is a fundamental source of cellular heterogeneity alongside gene expression levels. AS is closely linked to various physiological and pathological processes, including tumor progression and embryonic development. Single-cell RNA sequencing (scRNA-seq) technologies capture AS events through junction reads at cellular resolution, enabling the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40990037
DOI: 10.1093/gigascience/giaf110
PMCID: PMC12457822

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