Article

A functional genomics screen of human B-cell differentiation reveals convergent mechanisms of inherited childhood leukemia predisposition

2026-08-07

Abstract excerpt

B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer, yet the mechanisms by which inherited risk variants predispose to leukemia development remain poorly understood. A major challenge to studying these mechanisms has been the lack of model systems that faithfully capture the transient developmental states in which predisposition alleles are thought to act. Here, we establish a human B-c...

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Literature Corpus work: d169fd2d-eb52-5830-a271-0c4de16c8410
DOI: 10.64898/2026.08.06.743305

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