Article

The fetal specific gene <i>LIN28B</i> is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia

2024-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Infant ALL (iALL) is initiated in utero , most often by rearrangement of the KMT2A gene ( KMT2Ar ). It carries a very poor prognosis despite a lack of additional oncogenic driver mutations common in childhood ALL. Here, we aimed to identify specific properties of human fetal hematopoietic stem/progenitor cells (HSPC) that promote leukemic transformation in KMT2Ar iALL using molecular, functi...

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Literature Corpus work: 5713768c-8296-5f7a-85a5-79de89c1ff50
DOI: 10.1101/2024.09.18.613730

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