Article

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of leukemia

2020-04-22

Abstract excerpt

Human cancers arise through an evolutionary process whereby cells acquire somatic mutations that drive them to outgrow normal cells and create successive clonal populations. “Bottom-up” human cancer evolution models could help illuminate this process, but their creation has faced significant challenges. Here we combined human induced pluripotent stem cell (iPSC) and CRISPR/Cas9 technologies to develop a model of t...

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Literature Corpus work: 5ad5f1e7-ecfa-5c07-b2ad-245c954e9398
DOI: 10.1101/2020.04.21.051961

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