Article

Decoding human B cell ontogeny in prenatal and adult bone marrow and in vitro models via single-cell multiomics

2025-09-03

Abstract excerpt

In humans, the bone marrow becomes the primary site for B lymphopoiesis during the second trimester of pregnancy and continues throughout life. Prenatal and adult B cell progenitors play distinct roles in the aetiology and pathology of paediatric and adult hematopoietic malignancies, though the molecular drivers of these differences remain unclear. Here, we created a comprehensive multiomics atlas of over 500k cel...

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Literature Corpus work: 1b4042fe-421c-5f72-9683-99250312ae66
DOI: 10.1101/2025.08.31.672613

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