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Mechanistic insights into the developmental origin of pediatric hematologic disorders

24 Jul 2024

Abstract excerpt

Embryonic and fetal hematopoietic stem and progenitor cells differ in some key properties from cells that are part of the adult hematopoietic system. These include higher proliferation and self-renewal capacity, different globin gene usage, and differing lineage biases. Although these evolved to cover specific requirements of embryonic development, they can have serious consequences for the pathogenesis of...

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PMID: 39059457
DOI: 10.1016/j.exphem.2024.104583

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