Article

Dynamics of the B-Cell gene regulatory network in differentiation determine evolutionary trajectories of childhood leukaemogenesis

2026-05-25

Abstract excerpt

B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most frequent paediatric malignancy. Despite extensive molecular and cellular characterization a mechanistic model of leukaemogenesis has not yet been developed. Here we present a multi-valued logical model of B-cell differentiation, centred on a core pentad of transcription factors whose dysregulation results in the developmental arrest characteristi...

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Literature Corpus work: 9563e09c-7614-5ea9-b0fe-9daec442e4d2
DOI: 10.64898/2026.05.21.724796

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