Article
Molecular genetics of acute lymphoblastic leukemia.
Annual review of pathology - 1 Jan 2009
Teitell Michael A, Pandolfi Pier Paolo
Abstract excerpt
Acute lymphoblastic leukemia (ALL) is mainly a disease of childhood that arises from recurrent genetic insults that block precursor B and T cell differentiation and drive aberrant cell proliferation and survival. Recurrent defects including chromosomal translocations, aneuploidies, and gene-specific alterations generate molecular subgroups of B- and T-ALL with differing clinical courses and distinct responses to...
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