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Article

Transient Differentiation-State Plasticity Occurs during Acute Lymphoblastic Leukemia Initiation.

Cancer research - 15 Aug 2024

Poort Vera M, Hagelaar Rico, van Roosmalen Markus J, Trabut Laurianne, Buijs-Gladdines Jessica G C A M, van Wijk Bram, Meijerink Jules, van Boxtel Ruben

Abstract excerpt

Leukemia is characterized by oncogenic lesions that result in a block of differentiation, whereas phenotypic plasticity is retained. A better understanding of how these two phenomena arise during leukemogenesis in humans could help inform diagnosis and treatment strategies. Here, we leveraged the well-defined differentiation states during T-cell development to pinpoint the initiation of T-cell acute lymphoblastic...

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Source

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Identifiers

PMID: 38885294
DOI: 10.1158/0008-5472.CAN-24-1090
PMCID: PMC11325147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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