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Article

A RAG driver on the road to pediatric ALL.

Nature genetics - 1 Feb 2014

Kuiper Roland P, Waanders Esmé

Abstract excerpt

Genomic aberrations affecting genes in B cell differentiation are hallmarks of B-precursor acute lymphoblastic leukemia (ALL). A new whole-genome sequencing study of ETV6-RUNX1-positive ALL has now identified RAG-mediated recombination, which specifically targets genes and regulatory elements active during B cell differentiation, as the underlying mechanism.

Read the complete abstract on PubMed

Topics

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Share to Gene Rearrangement
Share to Genetic Variation
Share to Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

Share to Core Binding Factor Alpha 2 Subunit

Share to Gene Expression Regulation, Neoplastic

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Recombination, Genetic

Source

Identifiers

PMID: 24473322
DOI: 10.1038/ng.2879

Genes

ETV6
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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