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Article

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.

Nature communications - 8 May 2020

Shen Xueyi, Howard David M, Adams Mark J, Hill W David, Clarke Toni-Kim, Deary Ian J, Whalley Heather C, McIntosh Andrew M

Abstract excerpt

Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits...

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PMID: 32385265
DOI: 10.1038/s41467-020-16022-0
PMCID: PMC7210889

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