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Article

Correlation between polygenic risk scores of depression and cortical morphology networks.

Journal of psychiatry & neuroscience : JPN - 1 Jan 2025

Gong Qian, Wang Wei, Nie Zhaowen, Ma Simeng, Zhou Enqi, Deng Zipeng, Xie Xin-Hui, Lyu Honggang, Chen Mian-Mian, Kang Lijun, Liu Zhongchun

Abstract excerpt

BACKGROUND: Cortical morphometry is an intermediate phenotype that is closely related to the genetics and onset of major depressive disorder (MDD), and cortical morphometric networks are considered more relevant to disease mechanisms than brain regions. We sought to investigate changes in cortical morphometric networks in MDD and their relationship with genetic risk in healthy controls. METHODS: We recruited...

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PMID: 39753308
DOI: 10.1503/jpn.240140
PMCID: PMC11684925

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