Article

Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms

2019-02-21

Abstract excerpt

<h4>ABSTRACT</h4> Convergent data from imaging and postmortem brain transcriptome studies implicate corticolimbic circuit (CLC) dysregulation in the pathophysiology of depression. To more directly bridge these lines of work, we generated a novel transcriptome-based polygenic risk score (T-PRS), capturing subtle shifts towards depression-like gene expression patterns in key CLC regions, and mapped this T-PRS onto...

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Literature Corpus work: e3c60eeb-5241-57ee-a470-d8d6abd2f46d
DOI: 10.1101/556852

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