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Genetic risk scores of psychiatric phenotypes are associated with depression risk in a prospective Dutch population-based cohort.

Psychological medicine - 29 Sept 2025

Hofman Amy, Sedaghati-Khayat Bahar, Vreeker Annabel, Ikram M Arfan, Uitterlinden André G, van Meurs Joyce B J, van Rooij Jeroen G J, Luik Annemarie I

Abstract excerpt

BACKGROUND: Genetic risk scores hold potential for predicting depression in the general population. These scores must be validated for their associations with relevant characteristics of depression-related phenotypes, such as severity. We validated a genome-wide risk score (GRS) and a restricted polygenic risk score (PRS) for depression based on a meta-analysis of three genome-wide association studies and...

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Depression
Genetic Risk Score
Genome-Wide Association Study
Longitudinal Studies
Major Depressive Disorder

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PMID: 41017265
DOI: 10.1017/S0033291725101943
PMCID: PMC12527510

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