Article

Polygenic Risk Score Analysis for Major Depressive Disorder in a Chinese Cohort: Single-Phenotype and Pathway-Based Approaches

2026-06-15

Abstract excerpt

<title>Abstract</title> <p>Background Major depressive disorder (MDD) is a global mental health challenge characterized by high prevalence, disability, and recurrence, with its susceptibility showing substantial polygenic inheritance. Polygenic risk scores (PRS) provide a novel method to explore cumulative polygenic effects on MDD pathogenesis. Methods Initial study inclusion comprised 721 patients meeting Diag...

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Literature Corpus work: 07124efc-8376-5af7-a8d4-b015620cefab
DOI: 10.21203/rs.3.rs-9715227/v1

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