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Article

Neurodevelopmental signature of a transcriptome-based polygenic risk score for depression.

Psychiatry research - 1 Sept 2024

Miles Amy E, Rashid Sarah S, Dos Santos Fernanda C, Clifford Kevan P, Sibille Etienne, Nikolova Yuliya S

Abstract excerpt

Disentangling the molecular underpinnings of major depressive disorder (MDD) is necessary for identifying new treatment and prevention targets. The functional impact of depression-related transcriptomic changes on the brain remains relatively unexplored. We recently developed a novel transcriptome-based polygenic risk score (tPRS) composed of genes transcriptionally altered in MDD. Here, we sought to investigate...

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Identifiers

PMID: 38909414
DOI: 10.1016/j.psychres.2024.116030
PMCID: PMC11440511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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