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Microevolution of clade II isolates of <i>Candida auris</i> highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin B

2023-09-28

Abstract excerpt

Candida auris exhibits high-level resistance to amphotericin B (AmB). Mechanisms such as ergosterol biosynthesis malfunction, oxidative damage mismanagement, and increased drug efflux contribute to AmB resistance in C. auris . In this study, we experimentally evolved two East Asian drug-susceptible clade II isolates of C. auris (P2428 and CBS10913 T ) isolated from different geographical locations to develop re...

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Literature Corpus work
d15deea5-82b3-5b3a-9f54-29ff0e9b266a
DOI
10.1101/2023.09.20.558730
Open publication

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