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Genomic diversity across <i>Candida auris</i> clinical isolates shapes rapid development of antifungal resistance <i>in vitro</i> and <i>in vivo</i>

2022-03-26

Abstract excerpt

Antifungal drug resistance and tolerance poses a serious threat to global public health. In the human fungal pathogen, Candida auris , resistance to triazole, polyene, and echinocandin antifungals is rising, resulting in multidrug resistant isolates. Here, we use genome analysis and in vitro evolution of seventeen new clinical isolates of C. auris from clades I and IV to determine how quickly resistance mutatio...

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Literature Corpus work
bbe484a6-62c9-5ab4-ac3a-9428b5d00ea2
DOI
10.1101/2022.03.25.485898
Open publication

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Genomic diversity across <i>Candida auris</i> clinical isolates shapes rapid development of antifungal resistance <i>in vitro</i> and <i>in vivo</i>DOI 10.1101/2022.03.25.485898
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