Article
Multi-Omics Analysis of Experimentally Evolved Candida auris Isolates Reveals Modulation of Sterols, Sphingolipids, and Oxidative Stress in Acquired Amphotericin B Resistance.
Molecular microbiology - 1 Aug 2025
Chauhan Anshu, Carolus Hans, Sofras Dimitrios, Kumar Mohit, Kumar Praveen, Nair Remya, Narayanan Aswathy, Yadav Kusum, Ali Basharat, Biriukov Vladislav, Saini Amandeep, Leaves Ian, Vergauwen Rudy, Romero Celia Lobo, Malavia-Jones Dhara, Singh Ashutosh, Banerjee Atanu, Rudramurthy Shivaprakash M, Chakrabarti Arunaloke, Mondal Alok K, Gaur Naseem A, Sanyal Kaustuv, Rybak Jeffrey M, Gabaldón Toni, Van Dijck Patrick, Gow Neil A R, Prasad Rajendra
Abstract excerpt
Clinical isolates of Candida auris show a high prevalence of resistance to Amphotericin B (AmB)-an uncommon trait in most Candida species. Alterations in ergosterol biosynthesis can contribute to acquired AmB resistance in C. auris laboratory strains but are rarely seen in clinical isolates. In this study, we experimentally evolved two drug-susceptible Clade II isolates of C. auris to develop AmB resistance. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.