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What makes <i>Candida auris</i> pan-drug resistant? Integrative insights from genomic, transcriptomic, and phenomic analysis of clinical strains resistant to all four major classes of antifungal drugs

2024-06-18

Abstract excerpt

The global epidemic of drug-resistant Candida auris continues unabated. We do not know what caused the unprecedented appearance of pan-drug resistant (PDR) Candida auris strains in a hospitalized patient in New York; the initial report highlighted both known and unique mutations in the prominent gene targets of azoles, amphotericin B, echinocandins, and flucytosine antifungal drugs. However, the factors that all...

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Literature Corpus work
c56e1ed7-edb9-5fcb-8e7d-42560b2346fa
DOI
10.1101/2024.06.18.599548
Open publication

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What makes <i>Candida auris</i> pan-drug resistant? Integrative insights from genomic, transcriptomic, and phenomic analysis of clinical strains resistant to all four major classes of antifungal drugsDOI 10.1101/2024.06.18.599548
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