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<i>In vivo</i> emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in <i>Candida auris</i>

2021-10-09

Abstract excerpt

<h4>ABSTRACT</h4> Candida auris has emerged as a healthcare-associated and multidrug-resistant fungal pathogen of great clinical concern. While as much as 50% of C. auris clinical isolates are reported to be resistant to amphotericin B, to date, no mechanisms contributing to this resistance have been identified. We report here mutations in the C. auris sterol-methyltransferase gene, ERG6 , as the first identif...

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Literature Corpus work
31a068b7-d4fa-59b2-8865-9aaee9f01675
DOI
10.1101/2021.10.08.463721
Open publication

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