Acquired amphotericin B resistance and fitness trade-off compensation in Candida auris

Abstract excerpt

<title>Abstract</title> <p><italic>Candida auris</italic> is an emergent human fungal pathogen of growing concern due to common drug resistance to all major antifungal drug classes. Although resistance to amphotericin B (AMB) has been detected in 30 to 60% of clinical isolates of <italic>C. auris</italic>, mechanisms of AMB resistance remain poorly characterized. Here we present a large-scale investigation of how...

Topics

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• Amphotericin B
• Antifungal Agents
• Drug Resistance, Fungal
• Ergosterol
• Frameshift Mutation
• Fungal Proteins
• Microbial Sensitivity Tests
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

a6e9b706-57ae-5000-a0e8-2c10fc61b4b4

DOI

10.21203/rs.3.rs-3621420/v1