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Rare modification in the ergosterol biosynthesis pathway leads to amphotericin B resistance in <i>Candida auris</i> clinical isolates

2021-10-29

Abstract excerpt

<h4>ABSTRACT</h4> We determined amphotericin B (AmB) susceptibility and sequenced key genes of the ergosterol biosynthesis pathway implicated in AmB resistance ( ERG2, ERG3, ERG6, ERG11 ) of 321 clinical isolates of Candida auris . In antifungal susceptibility testing, 19 (5.9%) isolates were categorized as AmB-resistant (MIC ≥2 mg/l). Only one AmB-resistant isolate presented a unique non-wild-type ERG6 genoty...

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Literature Corpus work
f2ba5be5-1868-511f-bb83-bcd997e8a8b4
DOI
10.1101/2021.10.22.465535
Open publication

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