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Article

Genetic microevolution of clinical Candida auris with reduced Amphotericin B sensitivity in China.

Emerging microbes & infections - 1 Dec 2024

Tian Sufei, Rong Chen, Li Hailong, Wu Yusheng, Wu Na, Chu Yunzhuo, Jiang Ning, Zhang Jingping, Shang Hong

Abstract excerpt

The global rate of Amphotericin B (AmB) resistance in Candida auris has surpassed 12%. However, there is limited data on available clinical treatments and microevolutionary analyses concerning reduced AmB sensitivity. In this study, we collected 18 C. auris isolates from five patients between 2019 and 2022. We employed clinical data mining, genomic, and transcriptomic analyses to identify genetic evolutionary...

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Identifiers

PMID: 39234778
DOI: 10.1080/22221751.2024.2398596
PMCID: PMC11385638

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