Back to search

Article

Genome-wide analysis of experimentally evolved <i>Candida auris</i> reveals multiple novel mechanisms of multidrug-resistance

2020-09-30

Abstract excerpt

Candida auris is globally recognized as an opportunistic fungal pathogen of high concern, due to its extensive multidrug-resistance (MDR). Still, molecular mechanisms of MDR are largely unexplored. This is the first account of genome wide evolution of MDR in C. auris obtained through serial in vitro exposure to azoles, polyenes and echinocandins. We show the stepwise accumulation of multiple novel mutations in g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f3714358-5a46-5dcf-b4cd-6eb16d5ece07
DOI
10.1101/2020.09.28.317891
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genome-wide analysis of experimentally evolved <i>Candida auris</i> reveals multiple novel mechanisms of multidrug-resistanceDOI 10.1101/2020.09.28.317891
Genome-Wide Analysis of Experimentally Evolved Candida auris Reveals Multiple Novel Mechanisms of Multidrug Resistance.Semantic proximity
Exploration of novel mechanisms of azole resistance in Candida auris.Semantic proximity
Genomic diversity across <i>Candida auris</i> clinical isolates shapes rapid development of antifungal resistance <i>in vitro</i> and <i>in vivo</i>Semantic proximity
Mutations in <i>TAC1B</i> : a novel genetic determinant of clinical fluconazole resistance in <i>C. auris</i>Semantic proximity
Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris.Semantic proximity
A study of genomic complexity underlying multidrug resistance in Candida auris strains in Thailand.Semantic proximity
What makes <i>Candida auris</i> pan-drug resistant? Integrative insights from genomic, transcriptomic, and phenomic analysis of clinical strains resistant to all four major classes of antifungal drugsSemantic proximity
Acquired Amphotericin B Resistance Attributed to a Mutated <i>ERG3</i> in <i>Candidozyma auris</i>Semantic proximity
Microevolution of clade II isolates of <i>Candida auris</i> highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin BSemantic proximity
Micafungin exposure drives multidrug resistance in <i>Clavispora lusitaniae</i>Semantic proximity
Micafungin microevolution in Candida auris reveals resistance development without in vivo fitness compromise.Semantic proximity
Deciphering the multidrug resistance paradigm in Candida auris.Semantic proximity
Select a neighboring publication to make it the new centre.