Article

HUMAN SPINAL CORD ORGANOIDS REVEAL CELL INTERCALATION AS A CONSERVED MECHANISM FOR SECONDARY NEURULATION

2024-11-19

Abstract excerpt

<h4>SUMMARY</h4> Human pluripotent stem cells (hPSCs) have enabled major advances in neural organoid research, yet reconstructing spinal cord development in vitro remains challenging, as it requires mimicking the early environment of body axis elongation. Here, by exposing hPSCs to defined extrinsic signals, we directed their self-organizing capacity to generate organoids that recapitulate the transcriptional pro...

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Literature Corpus work: 69b29884-af67-51c6-b565-6ed2adc721ae
DOI: 10.1101/2024.11.19.624296

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