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Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD

11 Jun 2019

Abstract excerpt

Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are increasing in prevalence but lack targeted therapeutics. Although the pathological mechanisms behind these diseases remain unclear, both ALS and FTD are characterized pathologically by aberrant protein aggregation and inclusion formation within neurons, which correlates with neurodegeneration. Notably,...

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PMID: 31244593
DOI: 10.3389/fnins.2019.00548

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