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Article

Characterization of huntingtin interactomes and their dynamic responses in living cells by proximity proteomics.

Journal of neurochemistry - 1 Feb 2023

Xu Hongyuan, Bensalel Johanna, Raju Sunil, Capobianco Enrico, Lu Michael L, Wei Jianning

Abstract excerpt

Huntingtin (Htt) is a large protein without clearly defined molecular functions. Mutation in this protein causes Huntington's disease (HD), a fatal inherited neurodegenerative disorder. Identification of Htt-interacting proteins by the traditional approaches including yeast two-hybrid systems and affinity purifications has greatly facilitated the understanding of Htt function. However, these methods eliminated...

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Identifiers

PMID: 36437609
DOI: 10.1111/jnc.15726
PMCID: PMC10312121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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