Article

Subcellular proteomics of dopamine neurons in the mouse brain reveals axonal enrichment of proteins encoded by Parkinson’s disease-linked genes

2021-06-01

Abstract excerpt

Dopaminergic neurons modulate neural circuits and behaviors via dopamine release from expansive, long range axonal projections. The elaborate cytoarchitecture of these neurons is embedded within complex brain tissue, making it difficult to access the neuronal proteome using conventional methods. Here, we demonstrate APEX2 proximity labeling within genetically targeted neurons in the mouse brain, enabling subcellul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd1f008f-7fe7-5fa8-9305-8195c7f5b289
DOI: 10.1101/2021.06.01.446584

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Subcellular proteomics of dopamine neurons in the mouse brain reveals axonal enrichment of proteins encoded by Parkinson’s disease-linked genesDOI 10.1101/2021.06.01.446584Read

Dynamic proteomic and phosphoproteomic atlas of corticostriatal axon neurodevelopmentSemantic proximity Read

Protein composition of axonal dopamine release sites in the striatumSemantic proximity Read

Molecularly-guided spatial proteomics captures single-cell identity of the healthy and diseased nervous systemSemantic proximity Read

Cell type-specific biotin labeling <i>in vivo</i> resolves regional neuronal proteomic differences in mouse brainSemantic proximity Read

In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of α-synuclein Toxicity in Dopamine NeuronsSemantic proximity Read

Deep axonal proteomics of human iPSC-derived neurons by microfluidic separation and DIA-MSSemantic proximity Read

Tau interactome mapping reveals dynamic processes in synapses and mitochondria associated with neurodegenerative diseaseSemantic proximity Read

An Anatomically Resolved Mouse Brain Proteome Reveals Parkinson Disease-relevant PathwaysSemantic proximity Read

Global ubiquitylation analysis of mitochondria in primary neurons identifies physiological Parkin targets following activation of PINK1Semantic proximity Read

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologiesSemantic proximity Read

Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2 <sup>G2019S</sup> model of Parkinson’s diseaseSemantic proximity Read

Functional Genomics of Axons and Synapses to Understand Neurodegenerative DiseasesSemantic proximity Read