Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.

Nature communications - 6 Jun 2017

Woo Jung-A A, Liu Tian, Trotter Courtney, Fang Cenxiao C, De Narvaez Emillio, LePochat Patrick, Maslar Drew, Bukhari Anusha, Zhao Xingyu, Deonarine Andrew, Westerheide Sandy D, Kang David E

Abstract excerpt

Although multiple CHCHD10 mutations are associated with the spectrum of familial and sporadic frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) diseases, neither the normal function of endogenous CHCHD10 nor its role in the pathological milieu (that is, TDP-43 pathology) of FTD/ALS have been investigated. In this study, we made a series of observations utilizing Caenorhabditis elegans models,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frontotemporal Dementia

Share to Mitochondrial Proteins

Share to NIH 3T3 Cells

Share to Protein Domains

Share to Synapses

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 28585542
DOI: 10.1038/ncomms15558
PMCID: PMC5467170

Genes

CHCHD10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.PMID 28585542Read ↗

Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10Semantic proximity Read ↗

Cytoplasmic TDP-43 leads to early functional impairments without neurodegeneration in a Serotonergic Neuron-Specific <i>C. elegans</i> ModelSemantic proximity Read ↗

TDP-43 and PINK1 mediate CHCHD10S59L mutation-induced defects in Drosophila and in vitro.Semantic proximity Read ↗

Phosphorylation Promotes Neurotoxicity in a<i>Caenorhabditis elegans</i>Model of TDP-43 ProteinopathySemantic proximity Read ↗

Neurotoxic effects of TDP-43 overexpression in C. elegans.Semantic proximity Read ↗

Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice.Semantic proximity Read ↗

CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia.Semantic proximity Read ↗

Dominant toxicity of ALS–FTD-associated <i> CHCHD10 <sup>S59L</sup> </i> is mediated by TDP-43 and PINK1Semantic proximity Read ↗

Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion.Semantic proximity Read ↗

CHCHD2 and CHCHD10-related neurodegeneration: molecular pathogenesis and the path to precision therapy.Semantic proximity Read ↗

Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans.Semantic proximity Read ↗

CHCHD10P80L knock-in zebrafish display a mild ALS-like phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.