Article

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism

2025-07-07

Abstract excerpt

Dysregulation of the TAR DNA-binding protein 43 (TDP-43), including intraneuronal cytoplasmic mislocalisation and aggregation is a feature of multiple neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar dementia (FTLD), limbic-predominant age-related TDP-43 encephalopathy (LATE) and alzheimers disease (AD). Unravelling the causes and functional consequences of TDP-43 dysr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 134bedfb-8c18-51d2-8780-86c5781bd664
DOI: 10.1101/2025.07.06.663393

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanismDOI 10.1101/2025.07.06.663393Read

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism.Semantic proximity Read

Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.Semantic proximity Read

Mislocalisation of TDP-43 to the cytoplasm of either neurons or oligodendrocytes causes axonopathy and dysmyelinationSemantic proximity Read

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.Semantic proximity Read

TARDBP (TDP-43) Knock-in Zebrafish Display a Late-Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons.Semantic proximity Read

TDP-43 proteinopathies: a new wave of neurodegenerative diseasesSemantic proximity Read

Neuromuscular junction abnormalities in a zebrafish loss-of-function model of TDP-43Semantic proximity Read

Two neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosisSemantic proximity Read

Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficitsSemantic proximity Read

Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD.Semantic proximity Read

TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43Semantic proximity Read

TDP-43-mediated neuron loss in vivo requires RNA-binding activity.Semantic proximity Read