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Article

Neurotoxic effects of TDP-43 overexpression in C. elegans.

Human molecular genetics - 15 Aug 2010

Ash Peter E A, Zhang Yong-Jie, Roberts Christine M, Saldi Tassa, Hutter Harald, Buratti Emanuele, Petrucelli Leonard, Link Christopher D

Abstract excerpt

RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar dementia. We have engineered pan-neuronal expression of human TDP-43 protein in Caenorhabditis elegans, with the goal of generating a convenien...

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Source

Open in PubMed Open full text

Identifiers

PMID: 20530643
DOI: 10.1093/hmg/ddq230
PMCID: PMC2908471

Genes

CFTR
RRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20530643-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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