Article

Transgenic TDP-43 and endogenous TDP-1 Caenorhabditis elegans ALS models show motor deficits and age-dependent neurodegeneration

2022-04-20

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a progressive and selective loss of motor neurons. ALS is incurable and there are no effective treatments available for people living with the disease. About 90% of the cases are sporadic whereas 10% are familial, and patients usually die two to five years after symptom onset. Many genes are associated with ALS, including mut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84758f7b-f9bb-5b0e-8953-4c40c9f9a7d2
DOI: 10.21203/rs.3.rs-1555653/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transgenic TDP-43 and endogenous TDP-1 Caenorhabditis elegans ALS models show motor deficits and age-dependent neurodegenerationDOI 10.21203/rs.3.rs-1555653/v1Read

Phosphorylation Promotes Neurotoxicity in aCaenorhabditis elegansModel of TDP-43 ProteinopathySemantic proximity Read

TARDBP (TDP-43) Knock-in Zebrafish Display a Late-Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons.Semantic proximity Read

Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.Semantic proximity Read

Cytoplasmic TDP-43 leads to early functional impairments without neurodegeneration in a Serotonergic Neuron-Specific C. elegans ModelSemantic proximity Read

Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS.Semantic proximity Read

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism.Semantic proximity Read

Neurotoxic effects of TDP-43 overexpression in C. elegans.Semantic proximity Read

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanismSemantic proximity Read

A Drosophila model for TDP-43 proteinopathySemantic proximity Read

TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegansSemantic proximity Read

Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease modelsSemantic proximity Read

Transcriptomic Analysis of Zebrafish TDP-43 Transgenic LinesSemantic proximity Read