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Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models

19 Nov 2012

Abstract excerpt

The DNA/RNA binding proteins TAR DNA-binding protein 43 (TDP-43) and fused-in-sarcoma (FUS) are genetically linked to amyotrophic lateral sclerosis and frontotemporal lobar dementia, while the inappropriate cytoplasmic accumulations of TDP-43 and FUS are observed in a growing number of late-onset pathologies including spinocerebellar ataxia 3, Alzheimer's and Huntington's diseases (HD). To investigate if TDP-43...

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PMID: 23172908
DOI: 10.1093/hmg/dds485

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