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Phosphorylation Promotes Neurotoxicity in a<i>Caenorhabditis elegans</i>Model of TDP-43 Proteinopathy

1 Dec 2010

Abstract excerpt

Neurodegenerative disorders characterized by neuronal and glial lesions containing aggregated pathological TDP-43 protein in the cytoplasm, nucleus, or neurites are collectively referred to as TDP-43 proteinopathies. Lesions containing aggregated TDP-43 protein are a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U). In addition, mutations...

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PMID: 21123567
DOI: 10.1523/jneurosci.2911-10.2010

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