Article

Rebalancing the motor circuit restores movement in a <i>Caenorhabditis elegans</i> model for TDP-43-toxicity

2023-10-25

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia are caused by the abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm of neurons. How TDP-43 accumulation leads to disease symptoms is not well-characterized. Here, we use a C. elegans model for TDP-43-induced toxicity to identify the biological mechanisms that lead to disease-related phenotypes. By applying deep behavioral...

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Literature Corpus work: 6986cfd8-bda0-5515-b453-644f5f617c5a
DOI: 10.1101/2023.10.24.563563

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