Article

Calcium modulates intramolecular long-range contacts to form a polymorphic α-synuclein A53T fibril

2026-03-17

Abstract excerpt

Human α-synuclein (aSyn) is an intrinsically disordered protein, and aggregations of its amyloid fibrils are associated with Parkinson’s disease (PD). Apart from familial aSyn mutations, accumulated environmental calcium exacerbates aSyn aggregation and accelerates symptoms in aging PD patients. Here, we explored the effects of Ca 2+ ions on aSyn A53T, an aggregation-prone mutant variant, from disordered states t...

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Literature Corpus work: fc99e8b0-92e4-54df-a0c0-4c78d0e808fa
DOI: 10.64898/2026.03.14.711779

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