Article
In Vitro-Prepared A30P Alpha-Synuclein Fibrils Adopt the Conserved and Disease-Relevant Greek Key Fold.
The journal of physical chemistry. B - 16 Jul 2026
Milchberg Moses H, Warmuth Owen A, Borcik Collin G, Han Ruixian, Harding Benjamin D, DeZonia Barry, Dhavale Dhruva D, Pierson Joshua A, Kotzbauer Paul T, Wright Elizabeth R, Schwieters Charles D, Rienstra Chad M
Abstract excerpt
The pathological hallmark of Parkinson disease (PD) is the formation of the protein alpha-synuclein (Asyn) into β-sheet-rich, self-templating fibrils in the brain. Since the first atomic structure of wild-type Asyn fibrils was determined nearly a decade ago, several other in vitro structures of hereditary mutant fibrils and structures derived from post-mortem diseased patient tissue have been determined by...
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