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Article

Conserved core of amyloid fibrils of wild type and A30P mutant α-synuclein.

Protein science : a publication of the Protein Society - 1 Feb 2011

Cho Min-Kyu, Kim Hai-Young, Fernandez Claudio O, Becker Stefan, Zweckstetter Markus

Abstract excerpt

The major component of neural inclusions that are the pathological hallmark of Parkinson's disease are amyloid fibrils of the protein α-synuclein (aS). Here we investigated if the disease-related mutation A30P not only modulates the kinetics of aS aggregation, but also alters the structure of amyloid fibrils. To this end we optimized the method of quenched hydrogen/deuterium exchange coupled to NMR spectroscopy...

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PMID: 21280130
DOI: 10.1002/pro.570
PMCID: PMC3048423

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