Article
Mutant protein A30P α-synuclein adopts wild-type fibril structure, despite slower fibrillation kinetics.
The Journal of biological chemistry - 30 Mar 2012
Lemkau Luisel R, Comellas Gemma, Kloepper Kathryn D, Woods Wendy S, George Julia M, Rienstra Chad M
Abstract excerpt
α-Synuclein (AS) is associated with both sporadic and familial forms of Parkinson disease (PD). In sporadic disease, wild-type AS fibrillates and accumulates as Lewy bodies within dopaminergic neurons of the substantia nigra. The accumulation of misfolded AS is associated with the death of these neurons, which underlies many of the clinical features of PD. In addition, a rare missense mutation in AS, A30P, is...
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