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Article

G51D mutation of the endogenous rat <i>Snca</i> gene disrupts synaptic localisation of α-synuclein priming for Lewy-like pathology

2023-10-30

Abstract excerpt

Point mutations in the SNCA gene, encoding α-synuclein (αSyn), are a known cause of familial Parkinson’s disease. The G51D mutation causes early onset neurodegeneration with complex pathology. We used CRISPR/Cas9 in rats to introduce the G51D mutation into the endogenous Snca gene. Co-localisation immunostaining studies with synaptic proteins showed that αSyn G51D protein is no longer efficiently localised to s...

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Literature Corpus work
2db3c61b-fff7-5978-a3c8-4aa0f51317b7
DOI
10.1101/2023.10.27.564027
Open publication

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G51D mutation of the endogenous rat <i>Snca</i> gene disrupts synaptic localisation of α-synuclein priming for Lewy-like pathologyDOI 10.1101/2023.10.27.564027
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