Article

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

2019-01-16

Abstract excerpt

Progressive aggregation of the protein alpha-synuclein (α-syn) and loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) are key histopathological hallmarks of Parkinson’s disease (PD). Accruing evidence suggests that α-syn pathology can propagate through neuronal circuits in the brain, contributing to the progressive nature of the disease. Thus, it is therapeutically pertinent to identify modi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f36d1f97-44b9-53bd-b5fe-04574d91796b
DOI: 10.1101/522086

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LRRK2 modifies α-syn pathology and spread in mouse models and human neuronsDOI 10.1101/522086Read

Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-outSemantic proximity Read

LRRK2 and Protein Aggregation in Parkinson’s Disease: Insights From Animal ModelsSemantic proximity Read

SynucleinopathiesSemantic proximity Read

Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons.Semantic proximity Read

G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.Semantic proximity Read

G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice.Semantic proximity Read

α-Synuclein in Parkinson's Disease: Pathogenic Function and Translation into Animal ModelsSemantic proximity Read

α-Synuclein Pathology in Synucleinopathies: Mechanisms, Biomarkers, and Therapeutic ChallengesSemantic proximity Read

In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategiesSemantic proximity Read

Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.Semantic proximity Read

Modeling Parkinson’s Disease With the Alpha-Synuclein ProteinSemantic proximity Read

α-Synucleinopathy phenotypes.Semantic proximity Read