Article

Structural basis for peptide substrate specificities of glycosyltransferase GalNAc-T2

2020-06-27

Abstract excerpt

The polypeptide N- acetylgalactosaminyl transferase (GalNAc-T) enzyme family initiates O -linked mucin-type glycosylation. The family constitutes 20 isozymes in humans—an unusually large number—unique to O-glycosylation. GalNAc-Ts exhibit both redundancy and finely tuned specificity for a wide range of peptide substrates. In this work, we deciphered the sequence and structural motifs that determine the peptide s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d10624ea-634c-533f-a235-4c4610afe1aa
DOI: 10.1101/2020.06.25.171371

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural basis for peptide substrate specificities of glycosyltransferase GalNAc-T2DOI 10.1101/2020.06.25.171371Read

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.Semantic proximity Read

Review of Glycosylation Engineering of Biopharmaceuticals: Methods and Protocols : A book edited by Alain BeckSemantic proximity Read

Discovery and Development of Promiscuous O-Glycan Hydrolases for Removal of Intact Sialyl T-Antigen.Semantic proximity Read

Characterisation of CMP-sialic acid transporter substrate recognition.Semantic proximity Read

Phage display uncovers a sequence motif that drives polypeptide binding to a conserved regulatory exosite of O-GlcNAc transferaseSemantic proximity Read

Mutational analysis of the catalytic domain of O-linked N-acetylglucosaminyl transferase.Semantic proximity Read

Human OGA binds substrates in a conserved peptide recognition groove.Semantic proximity Read

Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.Semantic proximity Read

Exploration of O-GlcNAc transferase glycosylation sites reveals a target sequence compositional bias.Semantic proximity Read

Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycationSemantic proximity Read

Unveiling the Dynamical and Structural Features That Determine the Orientation of the Acceptor Substrate in the Landomycin Glycosyltransferase LanGT2 and Its Variant with C-Glycosylation Activity.Semantic proximity Read

Substrate recognition and cleavage by mucin degrading <i>O</i> -glycopeptidases from the gut microbe <i>Bacteroides caccae</i>Semantic proximity Read